Endocrine Abstracts

The prevalence of LOH among middle-aged men, who want to have kids, is increasing. According to HIM study (Mulligan T, Frick MF 2006), the prevalence of LOH is 34% in men, aged 45–54. There are 3 wide-spread forms of testosterone treatment of LOH: oral, i/m forms, and gels. Oral forms of treatment are known to have a rather weak effect. I/m forms of testosterone treatment have a significant negative effect on spermatogenesis down to azoospermia, causing decrease in LH and...

Introduction: Until 1996, men with Klinefelter syndrome (KS) were considered to be infertile, but with the development of testicular sperm extraction (TESE) and intracytoplasmatic sperm injection (ICSI) it is now possible to extract viable spermatozoa from the testes using surgical biopsy for the future injection into an ovum. A minority of men with KS have viable sperm in their ejaculate and might, therefore, be able to provide native sperm for ICSI.Mat...